Police were called at around 7.30am today (24 May) to reports of concerns for safety at a property on Gregg House Road, Shiregreen.
Yorkshire Ambulance Service and Yorkshire Air Ambulance have attended and transported six children to hospital.
Two people are under arrest.
There will be a significant police presence at the scene throughout the day as officers continue enquiries.
A cordon is in place and buses are being diverted from the area.
This incident is ongoing and further updates will be provided in due course.